Authors
Marian JE Mourits, Claudia B Bijen, Henriëtte J Arts, Henk G ter Brugge, Rob van der Sijde, Lasse Paulsen, Jacobus Wijma, Marlies Y Bongers, Wendy J Post, Ate G van der Zee, Geertruida H de Bock
Publication date
2010/8/1
Journal
The lancet oncology
Volume
11
Issue
8
Pages
763-771
Publisher
Elsevier
Description
Background
The standard surgery for early-stage endometrial cancer is total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy, which is associated with substantial morbidity. Total laparoscopic hysterectomy (TLH) and bilateral salpingo-oophorectomy is less invasive and is assumed to be associated with lower morbidity, particularly in obese women. This study investigated the complication rate of TLH versus TAH in women with early-stage endometrial cancer.
Methods
This randomised trial was done in 21 hospitals in the Netherlands, and 26 gynaecologists with proven sufficient skills in TLH participated. 283 patients with stage I endometrioid adenocarcinoma or complex atypical hyperplasia were randomly allocated (2:1) to the intervention group (TLH, n=187) or control group (TAH, n=96). Randomisation by sequential number generation was done centrally in alternate blocks of six and three …
Total citations
Scholar articles
MJE Mourits, CB Bijen, HJ Arts, HG ter Brugge… - The lancet oncology, 2010